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Pemphigus vulgaris

February 26, 2026
• Type: Autoimmune blistering disorder  • Autoantibodies: Against Desmoglein-3 (mucosa) ± Desmoglein-1 (skin) — components of desmosomes • Hypersensitivity type: Type 3 Hypersensitivity (Ag-Ab complex) • Blister type- Flaccid, Intraepidermal blisters    Pemphigus group of disorders  Pemphigoid group of disorders Bullae  Flaccid bullae Tense bullae (because whole epidermis  is present in bulla covering  so bulla is tight / tense) Bullae  […]
oxy Haemoglobin dissociation curve

Oxygen-hemoglobin dissociation curve

Oxygen-hemoglobin dissociation curve

February 26, 2026
  Shift Right Shift Left Shift Affection  for oxygen Decreased affinity Increased affinity Hb-oxygen  binding Oxygen is less tightly bound; more readily released Oxygen is more tightly bound;  less readily released  Causes – Increased CO2 – Decreased CO2   – Increased temperature – Decreased temperature   – Decreased pH (acidosis) – Increased pH (alkalosis)   […]
Brain 4th Ventricle, CDF Circulation

Third ventricle of brain

Third ventricle of brain

February 26, 2026
• Location: between the right and left thalami. • Extends from the interventricular foramen (of Monro) anteriorly → to the cerebral aqueduct (of Sylvius)posteriorly. Boundaries Formed by Roof • Choroid plexus • Fornix Floor Formed by hypothalmic structure-  • Optic chiasma • Infundibulum  • Tuber cinereum • Mammillary bodies  • Posterior perforated substance • Tegmentum of midbrain  Lateral wall • Thalamus (superior part) • Hypothalamus (inferior part) Anterior wall Anterior commissure […]
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